5/11/2023 0 Comments Omnidesk kenshi reviewThat’s not all – the controller dimming function auto-dims the buttons after 10 seconds of idle use, ensuring both electricity saving and a dark bedroom free of distractions when you sleep. Modern standing desks like the Omnidesk Pro 2020 even have accessible built-in USB ports strategically near the main work area, so you can check messages easily while charging your phone. To prevent such a predicament, look for tables that come equipped with cable management features that prevent an eyesore behind or under your desk. Your PC, monitors, phone, desk fan, humidifier or other gadgets you use all require cables which can cause a mess – adding an extension cord to the mix will tangle things up even more. Look for effective cable management features Omnidesk’s Pro 2020 series have smaller gaps between table columns, wide desk feet and an overall balanced frame that prevents unnecessary movement.įor extra safety, the desk also has a highly sensitive anti-collision function, so rest assured it won’t accidentally crush any of your barang barang underneath your desk on the way down.ĥ. Standing desks are especially prone to wobbles, but the more stable ones have carefully designed features for zero wobbles no matter the height. To prevent potential accidents as well as any annoying table-shakes while you’re typing away, you’ll want to make sure the desk doesn’t wobble. The last thing you’d want is to accidentally bump into your table and have your morning coffee spill all over your documents. Omnidesk is the only brand that allows you to choose from a compact 48″ (1.22m) to a larger 72″ (1.82m) to fit your space perfectly.Ĥ. ![]() While a desk with sufficient space is important, how it fits in your room is also something to take note of. You can also keep non-work things like a water bottle, a tissue box or even display your favourite plush toy while still having space to take down notes and even have lunch at your desk during crunch time. ![]() To prevent that, a desk with plenty of table space will let you place everything you need within arm’s reach, including any dual, triple or quadruple monitor setup you might have. On top of that, it’ll also ruin any neutral posture you might’ve had before which you may forget to maintain again.Īll the necessities, dual monitors and still space to spare on the Omnidesk Pro 2020 Wildwood. However, over time, this actually strains our muscles which can contribute to soreness or injury. Throughout the day while working, we may need to constantly lean forward and extend our arms to reach for documents or stationery within a tight constraint of space. Achieving the perfect eye-level monitor height is another important factor that can go a long way to reducing neck aches. In fact, adjustable desk heights like we mentioned above can also allow you to maximise ergonomics. One such example is an ergonomic curve, a slight tweak that better aligns your arms to their natural positions while working. ![]() Some desks have features that, while seemingly insignificant at first, actually help improve health and productivity based on extensive research. It may seem like a fancy word, but ergonomics aim to optimise the workstation to maximise our capabilities. Take note of ergonomics to maximise comfortĪn ergonomic curve on the Omnidesk Pro 2020 The 40% increase in movement speed means it’s the fastest in the market and allows quicker adjustments – it can even go low enough that you can treat it as a coffee table!Ģ. There are plenty of convertible standing desks available in the market, but Omnidesk’s range are motorised to take you from sitting to standing and vice versa in just seconds. The laundry list of benefits isn’t just limited to an improved posture – being on your feet more often also helps you stay alert, while reducing the risks of obesity and heart diseases. Studies have proven that there is a decrease in back and neck pains when at least 1 hour of standing is weaved into your day, which makes you wonder why more people haven’t turned to standing desks. But there’s a simple solution – standing desks. To reduce backaches and maximise productivity, take note of these tips on choosing the best home office desk and what features to look out for.Īnyone who has ever worked in an office setting can probably attest to the miserable backaches and posture-related issues experienced after sitting for an entire workday. We spend a lot of time in our offices beavering away at work without always noticing the small, minute ways in which the table can actually affect us. And the search for furniture to serve such a purpose usually begins with the centrepiece: an office desk. With the rise of work-from-home arrangements, many of us might be looking to redesign a portion of our home into an office.
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5/11/2023 0 Comments Boppio game![]() Additional Notes: Internet is only required for online play and cloud sync.Graphics: DirectX 10+ compatible graphics card.Processor: 2.8 GHz Intel Core i3 or Ryzen 3.Requires a 64-bit processor and operating system.Development blog for the base building game Boppio. If you need additional help, click here System Requirements Were working on Boppio, a factory building and automation game. Always disable your anti virus before extracting the game to prevent it from deleting the crack files. Also, be sure to right click the exe and always select “Run as administrator” if you’re having problems saving the game. Look for a ‘HOW TO RUN GAME!!.txt’ file for more help. You need these programs for the game to run. If you get any missing dll errors, make sure to look for a _Redist or _CommonRedist folder and install directx, vcredist and all other programs in that folder. NOTICE: This game is already pre-installed for you, meaning you don’t have to install it. ![]() Don't forget to run the game as administrator.
5/11/2023 0 Comments 3 across car seatsOur Elite Fleet includes compact car seats like the Graphene™, which maintain s narrow, compact, installed depth making it great for small cars requiring multiple seat configuration.Statewide - Colorado is receiving $51 million in federal funds for low- and zero-emission transit projects across the state, including a $34.8 million award to help the Summit County area transition to a 100% zero-emissions fleet. That is why Britax have car seats designed to be “three across the back” friendly. It also allows you to pick up any tips and advice the professional installer can offer you in order to fit three across the back.Įnsuring your three bundles of joy arrive to their desired destination safe-n-sound is the most important thing. Having your car seat fitted professionally ensures your car seat is installed safely. Tip 5: Take Advantage of Professional Installers.Ĭar safety experts strongly recommend having your child’s car seat fitted professionally by an accredited installer, at least for the first time. Looking out for our ISOFIX compatible car seats allow for easier installation, correct fit and a safer journey every time. Additionally, car seat installation can be made easier with ISOFIX. Alternating between rearward and forward facing seats where possible will mean that the widest part of the seats are not squashed side by side. Tip 4: Think about Positioning and InstallationĬonsider how you will position your car seats in order to make them fit comfortably. Our new advanced compact car seat Graphene™ has our narrowest footprint at only 285mm, making it perfect for cars with small internal widths. Some car seats are slimmer than others, and selecting compact designed car seats will make fitting three seats into the back of your car easier. ![]() Tip 3: Choose the Right Restraint for your Family ![]() Measure the back width and depth of your car seat so that you are certain of the space you have for your three car seats before purchasing. Finally, from 7 years of age, children can travel in a car secured in either a booster seat or the car’s adult seat belt if they reach the minimum height requirement of 145cm and can sit in an adult seat safely. From 4 years up to 8 years children must be secured in an approved, properly fastened and adjusted, forward-facing child car seat with an inbuilt harness or an approved booster seat which is properly positioned and fastened. If your child is 6 months – 4 years old, they require a rearward-facing child car seat or a forward-facing child car seat with an inbuilt harness. Children up to 6 months old must be secured in an approved, properly fastened and adjusted, rearward-facing child car seat. Understanding which car seats your children require is the first step. Don’t panic! There are a few tips (and particular car seats) that can make this process easier. Although welcoming a new family addition is exciting, keeping them safe on the move can be tricky when your car already has two child car restraints. One of the biggest challenges facing parents with growing families is considering how they will possibly add a third car seat to the back of their car. ![]() Want To Fit Three Car Seats Across The Back? Britax Has You Covered! Share on 5/11/2023 0 Comments Raindrop coloring pageAnd the rest of the palette will help color characters caught in the rain, their umbrellas, raincoats and rubber boots. To color the pictures from this page, you will need blue and blue paints for the clouds and the rain itself. After the rain, you can run through the puddles, launch paper boats, admire the rainbow. From simple and easy Spring images to elaborate adult designs, we have all of the best printable Rain Drops with Umbrella coloring pages. We hope you enjoy our online Coloring Books Get this free Spring Coloring Page and many more from PrimaryGames. It washes away dirt from city streets, fills rivers and seas, gives life-giving moisture to plants, and purifies the air. Download and print out this Rain Drops with Umbrella Coloring Page. Rain is very beneficial for the Earth and its inhabitants. It can be small and large, short or long, cold and warm. Gradually, the water cools down, small drops combine into large ones and fall down under their own weight. There, small droplets collect, forming small clouds or huge clouds. From the heat of the sun, water evaporates from the surface of reservoirs and rises up in the form of steam. All fonts and graphics are from these sellers, and Education Outside holds a commercial license.Coloring Pages Rain in all its glory show children one of the most common natural phenomena on the planet. Duplication for an entire school or commercial purposes is strictly forbidden without written permission from an authorized representative from Education Outside.Įvery printable worksheet is designed and created by the Education Outside team, but there are a few designers we would like to credit. These printables are created by Education Outside and are intended for one classroom/parent/tutor. You can print out and color this coloring page your own way. Free its raining coloring pages available for printing. You will receive a response as soon as possible. Color this picture of its raining coloring page with the colors of your choice. Please reach out to or message our team via the contact page. If you have any questions about a specific download or feel our team has incorrectly made something, please reach out, and we will work with customers on a situational basis. ~~~ Information About Refunds & Exchanges ~~~Įach download is non-refundable. If you do not have a laminating machine, use page protectors or any similar sleeve. Laminated products are best used with dry-erase markers. Some products are no-prep, whereas others may require you to laminate them before use. We highly recommend printing these worksheets on 8.5” x 11” standard paper. Once your payment has been processed, you will receive a link to download the PDF. Purchase the worksheet via our listing.Ģ. ~~~ How Will I Receive the Worksheet(s)? ~~~ġ. They also ask grownups all sorts of questions concerning why rain falls or why there is thunder. There will be no physical product shipped. Whether it be getting wet, or making paper boats or simply watching its steady downpour with inquisitive eyes, kids actively participate in all. Be sure to double-check the product listing before purchasing to ensure you are buying the correct one for your needs. Some worksheet sets will contain a colored version and/or black and white. You will receive a download link to your printable PDF. ~~~ What Do I Receive After Purchase? ~~~
5/11/2023 0 Comments Pcalc 208 leasing".PCalc represents the sort of innovative and creative spirit that we value most." Support for Macs with Apple Silicon or Intel processors.Handoff of in-progress calculations between PCalc on iOS, macOS, and watchOS.Full AppleScript and Shortcuts support for scripting.Smart searching of conversions, functions, and constants.A simulated paper tape to keep track of your calculations with a "ticker tape" mode under the main display.Hexadecimal, octal and binary modes, complete with a variety of bitwise operators.Editable user conversions, functions, and constants which are synced automatically across multiple devices.An RPN mode with one button access to the stack, and optional multiple-line display.Calculator themes - pick your look, all the way from minimalist to striking.A full button layout editor - make your own calculator to best suit your needs, sync it automatically with iPhone and iPad, and share it with others.Includes all the layouts from the iPhone and iPad, as well as Mac-specific ones. Switchable button layouts - choose from many different horizontal and vertical layouts.A powerful menu bar widget - do quick calculations without ever leaving your current app.It is a fully featured scientific calculator for macOS with support for hexadecimal, octal and binary calculations, as well as an optional RPN mode, parentheses, programmable functions, and an extensive set of unit conversions. This means that you need to take the time to find an auto policy that covers the car.PCalc 4 is a brand new version of my veteran calculator application. While our lease deals are cheap, they do not come with insurance. This type of lease is done in your name only and once the contract is up, you bring the car back to us and choose a new one or you can walk away free and clear. Your dream car is only a couple of clicks away when you apply for our personal contract hire option. If you choose the Peugeot e-208 you will benefit from 1% BIK tax in 2021/22 and 2% from 2022/23. This business lease deal is ideal for most companies and we can structure your contract to meet your needs. This is the best way to get into a company car and you will save yourself money too. If you have a business and it is already VAT registered, we recommend you choose our contract hire option. Peugeot e-208 and 208 Business Lease Deals If you have moderately bad credit, we may still be able to assist you. Our team will work closely with you to explore your options. Leasing a 208 with bad credit can happen but you may find that your options are limited. Leasing a Peugeot e-208 and 208 with Bad Credit ![]() We will work with you to find a payment plan that meets your needs and does not stretch your budget thin. ![]() If you are looking for a specific 208 model, you can narrow your search using the parameters above. Our system conveniently sorts all vehicles for you from low to high. We provide you with the best and cheapest Peugeot 208 lease deals and you can apply for any of our leasing deals now or view the current specials above. The 208 engine range is strong starting at 1.0L and scaling up to 1.6L, with the e-208 packing a 50kWh battery that provides over 200miles of range.Īll Peugeot 208 and e-208 cars leased through us come with an official manufacturer's warranty, free delivery and phone support throughout the duration of the lease contract. The car is well designed both inside and out, the interior is pleasing on the eye and very practical, allowing for family travel as well as commuting and leisure. The Peugeot 208 and all-electric Peugeot e-208 are strong contenders in the small car / super-mini category. 5/11/2023 0 Comments Dxo viewpoint 3 promotional code![]() ![]() It also offers a free trial with tutorials to know and learn the tools and how to edit the images for beginners. They provide High-Fidelity images, which makes the pictures more beautiful and creative. Using the DXO promotional code, you can save 10% on your purchase of the bundle that is included with DXO PureRaw and Nik Collection.ĭXO offers various software for simplifying the editing of images and improving the quality and clarity of the image by removing unnecessary noises and distortions. When we buy that bundle using the DXO promo codes, the price is reduced to $288.99. The price is less when compared to buying them individually. If you buy in bundles, for example, DXO Ultimate Bundle combines DxO ViewPoint, DxO FilmPack, and DxO PhotoLab, the price is $437, and you can get it at a lower price if you log in, as they provide discounts with DXO premium bundle promo code. You can start it by Signing up on their website, and they also provide updates and news regarding the DXO coupon codes, offers, and discounts. Other money-saving options are: Free Trial by SubscribingĭXO offers a free trial for 30 days with free tutorials. There are various DXO coupons and offers to provide you with the best discounts on their subscriptions and software. The price is $149, yet with the DXO Nik creative bundle coupon code, the shopping becomes much more friendly and affordable. It also corrects geometric distortions, lens sharpness, vignetting, and aberrations. The tools it offers are U-point Technology, Multi-purpose control points, smart copy and paste functionality, non-destructive editing, and more. It is a collection of 8 powerful plugins affordable with Nik collection promo code and gives you vast photographic potential. The price offered is $139, and they also provide additional discounts and offers to make the price pocket-friendly. Analog Photography displays a unique, interactive, and educational journey with a series of new effects through a Time machine. Through this, we can rediscover the magic of Analog with High-Fidelity in this present Digital world at an affordable price with DXO Film Pack coupon code. The price offered by DXO is $79, and the DXO viewpoint promo code can give you maximum savings on that price. It also automatically straightens the slanted horizon and restores the balance of the image. It helps strengthen the distorted perspectives automatically and restores the objects' natural shape at the sides and horizons. DxO also offers discounts on the products while making the shopping a budget-friendly one. With DXO pure raw coupon code, you can get this software for an affordable price even though the pricing of DXO PureRaw is $129. ![]() This software helps in easily editing the images. ![]() It also helps improve the image's quality in lens correction, demosaicing, and denoising. This software helps in giving us pure, flawless, noise-free raw photos at a flexible price with a DXO discount code. Some popular products you can find on DXO are: DXO PureRaw What Are The Products And Pricing On DXO?ĭelivering revolutionary technology for photoshop at affordable prices is the main aim of DXO. They offer different software, and using a DXO Photolab promotional code we can purchase according to our requirements at an affordable price. It also helps provide High-Fidelity by correcting chromatic aberrations, distortions, vignetting, and even loss of sharpness in the images. This software helps reduce digital noise, making the image more visible with colors. This company's software helps edit photos with sharpness and boosts your experience in image editing. If you want the best software to edit your pictures more creatively and beautifully, shop in DXO. What are the Tips to Save More on DXO Photo Editing Software? 5/11/2023 0 Comments Google vchat![]() In case you have any questions or need further assistance regarding LambdaTest + Google Chat integration, please feel free to reach us at our 24*7 Chat Support or email us at. The Google Chat integration will be uninstalled. Login to your LambdaTest account and visit Integrations from the left menu.įrom My Integrations, click REMOVE under the GOOGLE CHAT block. Hover on the LambdaTest bot and click on the Kebab menu.Click the Space name dropdown and then select View members.You will need to remove the existing LambdaTest bot in order to add it again in the same space. REPRODUCE LINK: To relaunch the test via a reproduce link.Īdding LambdaTest Bot On The Same Space GENERATED TICKET: To view the logged bugs in Issue Tracker. ![]() SCREENSHOT LINK: To view and download the screenshot. The test card contains the three features: Your bugs will now be marked and instant test card will be generated to your Google Chats or Google Chat Rooms. Furnish the details like Assignee, Issue Type, Priority, Summary, and Description. According to Wikipedia, Google Chat is a communication software developed by Google built for teams that provides.
![]() Power on the modem and wait for it fully restart. Connect the coax cable back to the modem. Unplug the power cable from the modem and the Medialink router. If you have a modem or modem/router combo unit, unplug the screw-in style coax cable from the back of the modem. What do I do if I still don't have internet and I don't have a computer with an Ethernet port?įirst double check that the cable from your internet source (modem, ethernet port on a wall, modem/router combo unit etc) is going to the BLUE WAN port on the Medialink router and not the yellow port. Power up the modem first and wait for it to fully restart and then power up the Medialink router and you should have internet. Power down your modem and your Medialink router. Find "MAC" and choose "Clone Local MAC Address" from the drop-down list. Once you get to the settings page, go to System Settings > WAN Settings. You may not have internet at this point, but you will still be able to get to the settings page of the router at or 192.168.8.1 in an internet browser. ![]() Then connect your computer to the YELLOW LAN port of the Medialink router. Once you have established that you can get to the internet with your computer, then put the Medialink router back into your network by connecting a cable from your modem or internet source directly to the BLUE WAN port on the Medialink router. If you don't have a computer with an Ethernet port, see the next FAQ question below. The first step is to connect a computer with an Ethernet cable to that internet source to make sure the internet is working to that computer directly (without the Medialink router or any other router in the middle). Your working Ethernet connection might come from a modem or from a port on the wall or a modem/router combo unit. If you are installing the unit as a normal primary Wireless Router you will need a working Ethernet connection. I've setup the router according to the instructions but why don't I have internet? 1 Gigabit per second (1 Gbps) is equal to 1000 Megabits per second (1000 Mbps). For example, 300 Mbps will have a faster wireless connection speed than 150 Mbps. Basically, the larger the amount, the faster the connection speed. Gbps, or Gigabits per second and Mbps, or Megabits per second, are units of data transfer rate. What are Gbps and Mbps and how do they affect routers? You will be prompted to create security passwords upon setup. Yes, this router supports the most current Security Protocols and Encryption Types to allow you to easily keep out unwanted intruders to your wireless network. ![]() Will my wireless internet be protected from intruders? Your router can support far more devices than your internet service provider can, so this will not be an issue. Yes, it will just require more bandwidth (a rate of data transfer). This router can cover most residential settings.Ĭan I wirelessly connect multiple devices? In a pure environment, this router can transmit data about 250-300 feet. It depends on many factors, including obstructions, neighboring networks, baby monitors and cordless phones. Your compatible devices will not need cables once the router is installed however, initial setup may involve some connectivity. The router needs to be connected to a power source and a modem in order to function. ![]() That way, you can access the internet wirelessly, with your computer, laptop, Smartphone and more. Internet Explorer 11+, Firefox 12.0+, Chrome 20.0+, Safari 4.It is made to connect devices to your online network without cables. Wi-Fi Router TL-WR841NPower AdapterRJ45 Ethernet CableQuick Installation Guide VIrtual ServerPort ForwardingPort TriggeringDMZUPnPĪddress ReservationDHCP Client ListServer SPI FirewallAccess ControlIP & MAC BindingApplication Layer Gateway Router ModeAccess Point ModeRange Extender ModeWISP Modeġ× 10/100 Mbps WAN Port4× 10/100 Mbps LAN Ports 5/10/2023 0 Comments 1920x800 aspect ratio calculator![]() If you know your seating distance, you can calculate the optimum screen size you will need:įor example, if your seating distance is 10 feet (120 inches), the screen height for HD should be 40 inches, which translates to a diagonal measurement of 80 inches for 16:9 or 100 inches for 2.39:1. These seating distances are the same for a 2.39:1 screen measuring 88 inches diagonally, because the height of the screen is still 35 inches.ġ0. If you know your screen size, you can calculate the optimum seating distance:įor example, a 16:9 screen measuring 70 inches diagonally has a height of about 35 inches, so the optimum seating distance for HD is 105 inches or 8.75 feet for UHD/4K images, the optimum seating distance is 52.5 inches or 4.4 feet. For 16:9 screens, the height is about half the diagonal measurement for 2.39:1 screens, the height is about 0.4 times the diagonal measurement.ĩ. The size of virtually all display screens is specified by their diagonal measurement. There are various formulas to calculate the optimum seating distance for the purpose of this list, I will use the ITU (International Telecommunications Union) recommendation of 3 times the screen height for HD and 1.5 times the screen height for UHD/4K, regardless of the screen's aspect ratio.Ĩ. ![]() ![]() This approach is more expensive than zooming, but it uses all the projector's pixels, giving the image more resolution and making it brighter.ħ. For 16:9 content, the anamorphic lens can be moved out of the way, or in the case of a fixed lens, the projector can electronically scale the image to the correct aspect ratio. The other way for a 16:9 projector to fill a wide screen with a widescreen image is to use an anamorphic lens, which optically stretches the image horizontally while the projector electronically upscales the image vertically. Some projectors have several "lens memories" that let you store and recall the zoom, focus, and lens-shift settings for content with different aspect ratios.Ħ. One way for a 16:9 projector to fill a wide screen with a widescreen image is to zoom the lens so the active image area fills the screen. Many projector owners get a 2.39:1 or 2.35:1 screen so that widescreen movies fill the screen without significant black bars.ĥ. I don't recommend this learn to live with the black bars to see the image as the content creator intended.Ĥ. With flat panels, this is unavoidable unless you use one of the TV's "zoom" functions, which either distort or crop parts of the image. If you watch both movies and TV shows, the aspect ratio of the image and screen won't always match when they don't, you will see black bars above and below or to the sides of the image, as shown above.ģ. A few flat-panel TVs have a native aspect ratio of 21:9, aka 2.33:1.Ģ. Almost all flat-panel TVs, home-theater projectors, and HDTV content have a native aspect ratio of 16:9, aka 1.78:1, while most movies are wider with a native aspect ratio of 1.85:1 or 2.39:1. The aspect ratio of a screen or image is the ratio of its width to its height. Aspect ratio, screen size, and seating distance are all important to keep in mind when planning or upgrading your home-theater sanctuary.ġ. 5/10/2023 0 Comments T dm1 mechanism of action![]() ![]() In February 2013, the US Food and Drug Administration (FDA) granted accelerated approval for ado-trastuzumab emtansine (Kadcyla Genentech, Inc), also known as T-DM1, for the treatment of patients with HER2-positive metastatic breast cancer who were previously treated with trastuzumab and with taxanes. 10įDA Approval of Ado-Trastuzumab Emtansine Fills an Unmet Need 9 Therapy alternatives include the combination of pertuzumab, trastuzumab, and a taxane lapatinib plus trastuzumab lapatinib plus capecitabine and the continued use of trastuzumab plus chemotherapy. 8Ĭurrently, treatment strategies for patients with trastuzumab-resistant HER2-positive breast cancer are selected on the basis of patient-specific factors (ie, age, comorbidities), disease- related factors, and cost. 7 Concerted efforts are under way to identify the mechanisms of trastuzumab resistance, as well as novel “druggable” targets for this patient population. In 2013, approximately 13,000 patients with HER2-positive metastatic breast cancer will have disease recurrence after trastuzumab treatment. However, primary and secondary resistance to trastuzumab occurs in the advanced breast cancer setting: none of these patients is cured. 4 In addition, 2 meta-analyses have confirmed the OS benefit of adding HER2-targeted therapy to standard treatment in patients with early-stage or metastatic HER2-positive breast cancer. 3 The first phase 3 clinical trial that compared trastuzumab plus chemotherapy versus chemotherapy alone in patients with HER2-positive metastatic breast cancer demonstrated robust improvements in response rate (50% vs 32%, respectively), median time to progression (7.4 months vs 4.6 months, respectively), and median overall survival ( 25.1 months vs 20.3 months, respectively) with the addition of trastuzumab. Much of the increased survival for patients with HER2-positive breast cancer is attributed to the development of HER2-targeted therapies, including trastuzumab (Herceptin), pertuzumab (Perjeta), and lapatinib (Tykerb). 2 Since 1989, death rates from breast cancer have declined, with relatively larger decreases in women aged <50 years, in part as a result of earlier detection and increasingly improved treatments. The American Cancer Society estimates that approximately 232,340 women will be diagnosed with invasive breast cancer, and approximately 39,620 deaths will occur from the disease in 2013. Unmet Need in Trastuzumab-Resistant Breast Cancer This protein is a cell-surface receptor that compels the tumor cell to grow and to divide more frequently than normal, making HER2-positive breast cancer an aggressive phenotype.īefore the advent of HER2-directed therapies, patients diagnosed with HER2-positive disease had significantly shorter disease-free survival compared with patients with other breast cancer subtypes. The HER2 gene, which resides on chromosome 17, directs tumor cells to manufacture HER2 protein. Approximately 25% of women who are diagnosed with breast cancer have HER2-positive tumors. |